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An intermediate for tetrahydro-L-biopterin; oxidized form of BH4, a NOS cofactor; toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs); rarely found under physiological conditions except in the epidermis of patients with Vitiligo
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An epoxide metabolite of DHA; formed from DHA by various CYP isoforms; suppresses hCLS formation and liver fibrosis in wild-type mice in a model of NASH at 100 ng/animal, i.p., intraplantar administration induces acute mechanical hyperalgesia in mice
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More